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An alien spaceship crash-lands in an isolated town in the middle of the Australian desert, releasing an insidious parasite that attacks the brain of all creatures including humans, making them disorientated, unnaturally strong and violent. Sargeant Jo Sharp, readying for a return to the big city beat, wakes to find the township, her family and friends falling victim to an evil that is spreading faster than it can be contained.

A fanatical animal rights activist releases giant pythons into the Everglades, believing the wild animals should be set free. When they start decimating the native animal population, an over-zealous park ranger feeds experimental steroids to wild alligators so they can fight back. The giant pythons and gargantuan alligators go on a killing spree, and it is now left up to the two feuding women to put aside their differences to put a stop to the creatures and the destruction.