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Twenty-eight weeks after the spread of a deadly rage virus, the inhabitants of the British Isles have lost their battle against the onslaught, as the virus has killed everyone there. Six months later, a group of Americans dare to set foot on the Isles, convinced the danger has passed. But it soon becomes all too clear that the scourge continues to live, waiting to pounce on its next victims.

Jamie returns to his hometown in search of answers to his wife's murder, which occurred after receiving a weird package containing a ventriloquist dummy named Billy, which may be linked to the legend of ventriloquist Mary Shaw. Destined to find out the truth, Jamie goes to the town of Raven's Fair, where Shaw used to perform and is buried. But Jamie is in for more than he expected.

A young couple travels to a shabby Eastern European hospital for plastic surgery. The young woman wants a breast reduction. Her mother comes along for yet another face-lift. Wandering through an abandoned ward the boyfriend stumbles upon a young woman, gagged and strapped to an operating table; she is the result of an experimental rejuvenation treatment. He frees her, but does not realize he just caused the outbreak of a virus that will change doctors, patients and his mother-in-law into bloodthirsty zombies.